Research Contract for Mycobacterial Determinants of Survival and Fitness within the Bovine Host
Awarded 31 Mar 2016
About
The Department for Environment, Food & Rural Affairs awarded a contract to APHA for research on mycobacterial determinants of survival and fitness within the bovine host.
The project uses Transposon Directed Insertion Sequencing (TraDIS) to determine M.
bovis gene fitness and essentiality in disease-relevant models of natural infection.
The objectives include constructing and validating a large transposon library of M.
bovis, deriving an essential gene list, identifying essential genes in in vitro and ex vivo models, validating these datasets, and identifying essential genes in the bovine host.
The contract value is £250,290.48.
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