Research Contract for Mycobacterial Determinants of Survival and Fitness within the Bovine Host

Awarded 31 Mar 2016

View live tenders
Awarded31 Mar 2016
Value£250,290.48
SupplierAPHA
RegionUnited Kingdom
CategoryResearch & Development
Ended 6y 7mo ago4y term
Awarded 31 Mar 2016Expired 30 Mar 2020

The Department for Environment, Food & Rural Affairs awarded a contract to APHA for research on mycobacterial determinants of survival and fitness within the bovine host.

The project uses Transposon Directed Insertion Sequencing (TraDIS) to determine M.

bovis gene fitness and essentiality in disease-relevant models of natural infection.

The objectives include constructing and validating a large transposon library of M.

bovis, deriving an essential gene list, identifying essential genes in in vitro and ex vivo models, validating these datasets, and identifying essential genes in the bovine host.

The contract value is £250,290.48.

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