Tender: MHRA Supply and Maintenance of Two Mass Spectrometry Systems — High‑Resolution LC‑MS and Triple Quadrupole UPLC‑MS

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The MHRA is seeking a supplier for the provision and maintenance of two mass spectrometry systems to replace two existing triple quadrupole instruments (s/n TQH-Q1-0526 and TQH-Q1-0525) for quantification and characterisation of biological medicine standards, including influenza, and to support counterfeit and sub-potent medicine characterisation. The contract covers purchase of: System 1, a high-resolution mass spectrometer coupled with a low-flow liquid chromatography system, including all instrumentation and software for qualitative and quantitative analysis across complex biological matrices (proteomics, intact protein analysis, biopharmaceutical characterisation including multi-attribute monitoring of therapeutic antibodies, post-translational modifications, small molecules/metabolomics, glycoproteins and oligonucleotides); and System 2, a triple quadrupole mass spectrometer coupled with ultra-high performance liquid chromatography, including all instrumentation and software for high-throughput targeted quantitative analysis across biopharma, clinical and small molecule applications supporting large SRM/MRM panels, with service maintenance and any bespoke consumables required to run the systems.