Supply of Doxycycline & Placebo for the AFLOAT Trial

About

The University of Southampton awarded a contract to Modepharma Limited for the supply of Doxycycline and matching placebo for the AFLOAT Trial, a publicly-funded (NIHR) and academic-sponsored Clinical Trial of an Investigational Medicinal Product (CTIMP).

The trial aims to assess whether time until all symptoms are rated absent or mild is no worse in those who take placebo versus antibiotics in adults aged 65 and over who are seen in primary care with lower respiratory tract infection (LRTI) and risk factors for complications.

Patients with LRTI will be recruited from primary care sites and randomised to receive either Doxycycline (100mg twice a day on the first day and then 100 mg once a day for 4 days) or matching placebo.

The drugs will be identical in taste and appearance and stored in sealed blind-sequence medication containers holding a 5-day supply of either doxycycline or placebo.

The contract value is AUD 64,590.